R-407C is a non-ozone depleting blend of three hydrofluorocarbon (HFC) refrigerants and an alternative for R-22 in positive displacement air-conditioning (AC) equipment. It is currently being used in commercial and light commercial AC units using air cooled direct expansion (DX) chillers. R-407C can also be used in many medium-temperature refrigeration systems that formerly used R-22. R-407C can also be used to replace R-502 in new and existing medium-temperature applications with evaporator temperatures above -6.7°C.

R-407C has been a popular R-22 replacement because of its properties, which include:

• Similar cooling capacity, energy efficiency, and pressures as R-22 in systems
• An ability to be topped off after a leak with minimal impact on system performance
• Safety: R-407C has an ASHRAE A1 safety classification

R-407C refrigerant performs similarly to R-22 under evaporator temperatures ranging from –7 to 10 °C. It is designed for use in new equipment and as a service refrigerant for existing HCFC-22 air conditioning, heat pump, and medium temperature refrigeration equipment.