R-410A is a non-ozone depleting blend of two hydrofluorocarbon (HFC) refrigerants. It exhibits higher pressures and refrigeration capacity than R-22. R-410A is intended for use in new air conditioning applications that have traditionally been serviced by R-22. Many other applications are also possible, such as medium- and low-temperature refrigeration. Due to the significantly higher pressures that R-410A exhibits compared to R-22, a typical compressor designed for R-22 cannot be used with R-410A.

R-410A refrigerant offers higher cooling capacity and significantly higher pressure than R-22 for use in systems specifically designed for R-410A. This HFC refrigerant is compatible with polyolefin (POE) oils and replaces R-22 in positive displacement air conditioning (AC) and heat pump systems for residential and light commercial use.