R22 has been the dominant refrigerant in residential and commercial air conditioning and some very large centrifugal chillers for air conditioning and industrial process cooling. It has also been used in refrigeration since the phase-out of CFCs, both as a pure refrigerant and in blends. R22 is subject to reduced production and restriction in new equipment since 2010, and production ended in 2020. The use of R22 is allowed until the R22 supply has been depleted.
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